Showing posts with label experiment in pharmacology. Show all posts
Showing posts with label experiment in pharmacology. Show all posts

Saturday, July 12, 2008

Fungi Makes for Fun Guys

by Leane Scoz

Psilocybin mushrooms, a.k.a. shrooms, magic mushrooms, boomers, can be traced back a million years, originating in East Africa. The fungi have been widely eaten by Europeans and Native Americans in Central and South America since the late 18th century. Psychedelic mushrooms eventually made their way to the United States and became a popular recreational drug during the 1960s with the advent of the hippie era.

The use of psychedelic mushrooms is subjective and unpredictable. The hallucinogenic experience can produce effects that are physical, sensory, emotional, and psychological. Although their consumption is illegal in most countries, including the United States, shrooms have been the subject of several psychedelic research projects in recent years.

A 2006 press release from Johns Hopkins University outlined a rigorous scientific study involving 36 college educated men and women and showed how the mushrooms produced mystical/spiritual experiences for research subjects. According to the National Institute on Drug Abuse (NIDA), the research marked a new systematic approach to studying certain hallucinogenic compounds and showed signs of therapeutic potential and value in research into the nature of consciousness and sensory perception.

A recent Associated Press article summarized a report published on July 1, 2008 in the Journal of Pharmacology that provided follow-up to the initial study. The report showed that more than 60 percent of the research subjects reported substantial increases in life satisfaction since the psilocybin experiment. The volunteers reported feeling more creative, self-confident, flexible, and optimistic. They also indicated that they felt more sensitive, tolerant, loving and compassionate since their hallucinogenic research experience.

According to a Newsweek article related to the same research project, the study of hallucinogenic compounds is and has always been controversial despite their potential to reveal secrets of the conscious mind. This is largely due to the federal government's decision to make hallucinogenic drugs, such as psilocybin and LSD, illegal in the 1960s after heavy persuasion by the media. Psychedelic research is not easily funded or sponsored and, until these recent published findings, this type of research has been difficult to legitimize.

Why do scientists continue to pursue this avenue of research? Because of the findings in research projects such as the Johns Hopkins experiment, psilocybin has shown promise in treating conditions including Obsessive Compulsive Spectrum Disorders (OCSD), anxiety in terminally ill cancer patients, and Post-Traumatic Stress Disorder (PTSD).

Thursday, April 10, 2008

Nature Reports Use of Brain-Boosting Drugs

image from nature.comAccording to a new report in Nature, one in five people surveyed have used drugs to boost their mental cognition - and while we know that most people using brain boosting drugs recreationally/academically are students in the 18-25 bracket, there is a (perhaps not) surprising number of academics reporting casual/non-medical use of drugs like Ritalin and Adderall. The study was informal, nonspecific, and international, and most of the 1400 people who responded said that they worked in some medical or education related field, and took the drugs to improve their concentration.

Martha Farah director of UPenn's Center for Cognitive Neuroscience, calls this "America's uncontrolled experiment in pharmacology." The drugs are risky, being taken in an unsupervised manner, and no one really knows what they will do or the long term side effects of taking them on a neurocognitively normal brain. And even more to the point, no one knows where people are receiving their supplies - the internet? Are they even getting what they ordered?

Brendan Maher thinks this is just our competitive nature coming out, wanting something that no one else can have and doing our best to achieve it - or at least take it away from them. I'm not necessarily convinced this is it, or at least all of it - it seems that it is our keeping up with the neighbour instincts coming out, and the desire to make sure we're doing everything we can to be in a competitively even situation with those around us.

Still, given how easy it is for off-share pharmaceuticals to become contaminated, or not made of of the basic ingredient in the first place, the lack of medical supervision and lack of long term followup is worrying. We simply don't know what these drugs will do long term, and what the consequences will be not only for the user but, at least in the case of medical professionls, the people that they treat.
-Kelly Hills